Journal of Gene Medicine

Gene Therapy Review

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Saturday, 31 July 2010

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J Gene Med

The Journal of Gene Medicine publishes high quality original articles and reviews on the science of gene transfer and its applications in gene and cell therapy. Key areas of interest are the design and production of vectors, delivery and targeting, gene expression and regulation, preclinical studies including animal models, developmental aspects and clinical trials.

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Complete regression of human malignant mesothelioma xenografts following local injection of midkine promoter-driven oncolytic adenovirus
Malignant mesothelioma is a highly aggressive tumor with poor prognosis. We hypothesized that the tumor-specific midkine (Mdk) promoter could confer transcriptional targeting to oncolytic adenoviruses for effective treatment of malignant mesothelioma.We analysed Mdk expression by quantitative reverse transcription-polymerase chain reaction in six human mesothelioma cell lines, and tested Mdk promoter...
Investigation of polyethylenimine-grafted-triamcinolone acetonide as nucleus-targeting gene delivery systems
Nuclear membrane is one of the main barriers in polymer mediated intracellular gene delivery. To improve the transgenic activity and safety of nonviral vector, triamcinolone acetonide (TA) as a nuclear localization signal was conjugated with different molecular weight polyethylenimine (PEI).Different molecular weight PEI [600, 1800, 25 000 (25k)] was conjugated...
Lentiviral airway gene transfer in lungs of mice and sheep: successes and challenges
Persistent airway gene expression can be achieved in mouse nasal airway using a vesicular stomatitis virus glycoprotein pseudotyped lentiviral (LV) gene vector in combination with lysophosphatidylcholine (LPC) pretreatment. We have now examined the acute in vivo effects of this combination single-dose method for airway LV gene transfer in mouse and...
Intra-articular electrotransfer of mouse soluble tumour necrosis factor receptor in a murine model of rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and destruction of the joints. In the collagen-induced arthritis mouse model of RA, we developed a nonviral gene therapy method designed to block in situ the main cytokine tumour necrosis factor (TNF)-[alpha]Electrotransfer was used to deliver a plasmid encoding...
Modeling of congenital erythropoietic porphyria by RNA interference: a new tool for preclinical gene therapy evaluation
Congenital erythropoietic porphyria (CEP) is a severe autosomal recessive disorder characterized by a deficiency in uroporphyrinogen III synthase (UROS), the fourth enzyme of the heme biosynthetic pathway. We recently demonstrated the definitive cure of a murine model of CEP by lentiviral vector-mediated hematopoietic stem cell (HSC) gene therapy. In the...

J Gene Med

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